Role of Tumor-derived Exosomal Long Non-coding RNA in Tumor Microenvironment
GUO Meng-Qi1), REN Wei-Hong2)*, HE Jiao1)
1)Laboratory of Tumor Molecular Diagnosis Technology, First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou 450046, China; 2)Department of Clinical Laboratory, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
Abstract：Exosomes are cell-secreted nano-scale vesicles which are rich in a variety of biologically active substances and function as the important mediators in cell-to-cell communication. Long non-coding RNAs (lncRNAs) have impacts on the tumorigenesis and tumor progression from various aspects, and are specifically sorted into exosomes. Tumor microenvironment (TME), an internal environment composed of tumor cells, non-tumor cells (such as endothelial cells, immune cells, fibroblasts, etc.) and extracellular matrix, plays a vital role in the tumorigenesis and tumor progression. Tumor cells secrete large amounts of exosomes into TME. This article summarizes the roles of tumor-derived exosomal lncRNAs in TME from the perspective of how they regulate receptor cells, such as promoting tumor metastasis, drug resistance, cell metabolic reprogramming, tumor stemness, epithelial to mesenchymal transition (EMT), tumor angiogenesis and lymphangiogenesis, and immunosuppression. An in-depth understanding of the role of tumor-derived exosomal lncRNA in TME will help to provide potential new clinical biomarkers and therapeutic targets for cancer.
郭梦琦, 任伟宏, 贺娇. 肿瘤外泌体lncRNA在肿瘤微环境中的作用[J]. 中国生物化学与分子生物学报, 2021, 37(12): 1601-1610.
GUO Meng-Qi, REN Wei-Hong, HE Jiao. Role of Tumor-derived Exosomal Long Non-coding RNA in Tumor Microenvironment. Chinese Journal of Biochemistry and Molecular Biol, 2021, 37(12): 1601-1610.
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