Exercise, Mitochondrial Transcription Factor A and Skeletal Muscle Atrophy
HE Shi-Yi 1),2) , ZHANG Ying 1)*
1）Sport Science College of Beijing Sport University, Beijing 100084, China；2)China Academy of Sport and Health Sciences of Beijing Sport University, Beijing 100084, China
Abstract：Skeletal muscle atrophy is caused by a host of factors including diseases, aging, injury, nutritional decrement and muscle disuse. The mitochondrial dysfunction is associated with the occurrence and development of skeletal muscle atrophy. Mitochondrial transcription factor A (TFAM or mTFA), as an important transcription factor, can interact with mitochondrial DNA (mtDNA), which regulates the replication and transcription of mtDNA and maintains the normal functions of mitochondria. TFAM is closely associated with atrophy of skeletal muscle. Exercise is an efficient, economical, convenient and feasible method to prevent skeletal muscle atrophy. Exercise may promote the expression and biological functions of TFAM in skeletal muscle by improving the expression of peroxisome proliferator activated receptor gamma coactivator-1 alpha (PGC-1α), a well-known activator of the transcription of TFAM and mitochondrial biogenesis, and heat shock proteins (HSPs) which is to protect and transport TFAM. Exercise may also change the epigenetic modifications of TFAM, such as changing the expression of microRNAs, DNA methylation and protein phosphorylation, glycosylation, ubiquitination, and so on. Therefore, this review summarized the role of TFAM in skeletal muscle atrophy and the effects of exercise on its expression.
何诗依，张缨. 运动、线粒体转录因子A与骨骼肌萎缩[J]. 中国生物化学与分子生物学报, 2019, 35(8): 837-842.
HE Shi-Yi, ZHANG Ying. Exercise, Mitochondrial Transcription Factor A and Skeletal Muscle Atrophy. Chinese Journal of Biochemistry and Molecular Biol, 2019, 35(8): 837-842.
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