（Center for Mitochondrial Biology and Medicine, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an710049, China）
Abstract：Reactive oxygen species (ROS) are highly reactive molecules produced in cell metabolism, thus make surrounding molecules vulnerable to oxidation. ROS are involved in various intracellular signal transduction pathways, and are believed to be important regulators of physiological processes. Autophagy is the degradation and recycling of components in eukaryotes through the lysosome system, and is a key player in cellular response to stress and the pathogenesis of related diseases. In this paper we reviewed the latest studies about ROS and autophagy-related regulation, focusing on autophagy modulation mediated by ROS as signal molecules, especially on signal transduction mechanisms involved in ROS-induced autophagic cell death, autophagic cell survival and mitophagy.
纪元，龙建纲，刘健康. 自噬发生中的ROS调节机制[J]. 中国生物化学与分子生物学报, 2014, 30(4): 321-327.
JI Yuan, LONG Jian-Gang , LIU Jian-Kang . The Role of Reactive Oxygen Species in Autophagy. Chinese Journal of Biochemistry and Molecular Biol, 2014, 30(4): 321-327.
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