The emerging roles of health informatics (or medical informatics) in disease controls are becoming more and more important and indispensable, especially during the current outbreak of type A influenza. Based on the most updated data collected from multiple biomedical databases, this article provided in-depth bioinformatic analyses of the molecular evidence related to the origin, evolution, spreading and prevention of current novel influenza A viruses. Meanwhile, introductions and comments on the potential of health informatics in disease controls were emphasized. It is expected to be a useful reference for the researchers of various disciplines in related biomedical fields.