LI Na 2), ZHANG Ying Tao 2), XUE Li Xiang 1)*, TONG Tan Jun 1)
(1)Department of Biochemistry and Molecular Biology, Peking UniversityResearch Center on Aging, 2)Department of pharmacy, Peking University Health Science Center, Beijing 100083, China)
Abstract: Most normal somatic cells possess a limited proliferative lifespan after which they enter into a state of terminal growth arrest known as replicative senescence. Three putitive signaling pathways related to cell replicative senescence are p16INK4a/Rb,p19ARF/p53/p21Waf1 and PTEN/p27. There are some new observations recently.Firstly,in the gene transcription level, the domains of certain transcription factors play important roles in the gene expression such as p16INK4a,p53/p21Waf1 and p27,for example,E2DBD,RING finger andso on.Secondly, activation of each pathway must rely on the protein interactions between its upstream and downstream components in which the protein domains are the key factor.Some of these domains are described here; in the end,other protein domains related to cell senescense are summarized.
李娜,张英涛,薛丽香,童坦君. 参与细胞衰老的蛋白质结构域[J]. 中国生物化学与分子生物学报, 2007, 23(03): 177-180.
LINa,ZHANGYingTao,XUELiXiang,TONGTanJun. Protein Domains Participated in Cell Senescence. Chinese Journal of Biochemistry and Molecular Biol, 2007, 23(03): 177-180.