［1］   Lapidot M,Pilpel Y.Genome-wide natural antisense transcription: coupling its regulation to its different regulatory mechanisms ［J］.EMBO Rep, 2006, 7(12): 1216-1222 ［2］   Katayama S,Tomaru Y,Kasukawa T, et al.Antisense transcription in the mammalian transcriptome［J］.Science, 2005, 309(5740): 1564-1566 ［3］   Carninci P,Kasukawa T,Katayama S, et al.The transcriptional landscape of the mammalian genome ［J］.Science, 2005, 309(5740): 1559-1563 ［4］   Chen J,Sun M,Kent W J, et al.Over 20% of human transcripts might form sense-antisense pairs ［J］.Nucleic Acids Res, 2004, 32(16): 4812-4820 ［1］   He Y,Vogelstein B,Velculescu V E, et al.The antisense transcriptomes of human cells ［J］.Science, 2008, 322(5909): 1855-1857 ［6］   Okada Y,Tashiro C,Numata K, et al.Comparative expression analysis uncovers novel features of endogenous antisense transcription ［J］.Hum Mol Genet, 2008, 17(11): 1631-1640 ［7］   Ge X,Wu Q,Jung Y C, et al.A large quantity of novel human antisense transcripts detected by LongSAGE ［J］.Bioinformatics, 2006, 22(20): 2475-2479 ［8］   Sun M,Hurst L D,Carmichael G G, et al.Evidence for variation in abundance of antisense transcripts between multicellular animals but no relationship between antisense transcriptionand organismic complexity ［J］.Genome Res, 2006, 16(7): 922-933 ［9］   Wang X J,Gaasterland T,Chua N H.Genome-wide prediction and identification of cis-natural antisense transcripts in Arabidopsis thaliana ［J］.Genome Biol, 2005, 6(4): R30 ［10］   Osato N,Yamada H,Satoh K, et al.Antisense transcripts with rice full-length cDNAs ［J］.Genome Biol, 2003, 5(1): R5 ［11］   David L,Huber W,Granovskaia M, et al.A high-resolution map of transcription in the yeast genome ［J］.Proc Natl Acad Sci U S A, 2006, 103(14): 5320-5325 ［12］   Smith CA,Robertson D,Yates B, et al.The effect of temperature on Natural Antisense Transcript (NAT) expression in Aspergillus flavus ［J］.Curr Genet, 2008, 54(19): 241-269 ［13］   Perlot T,Li G,Alt F W.Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions ［J］.Proc Natl Acad Sci U S A, 2008, 105(10): 3843-3848 ［14］   Prescott E M,Proudfoot N J.Transcriptional collision between convergent genes in budding yeast ［J］.Proc Natl Acad Sci U S A, 2002, 99(13): 8796-8801 ［15］   Tufarelli C,Stanley J A,Garrick D, et al.Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease ［J］.Nat Genet, 2003, 34(2): 157-165 ［16］   Swiezewski S,Liu F,Magusin A, et al.Cold-induced silencing by long antisense transcripts of an Arabidopsis Polycomb target ［J］.Nature, 2009, 462(7274): 799-802 ［17］   Uchida T,Rossignol F,Matthay M A, et al.Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha ［J］.J Biol Chem, 2004, 279(15): 14871-14878 ［18］   Borsani O,Zhu J,Verslues P E, et al.Endogenous siRNAs derived from a pair of natural cis-antisense transcripts regulate salt tolerance in Arabidopsis ［J］.Cell, 2005, 123(7): 1279-1291 ［19］   Hastings M L,Milcarek C,Martincic K, et al.Expression of the thyroid hormone receptor gene, erbAalpha, in B lymphocytes: alternative mRNA processing is independent of differentiation but correlates with antisense RNA levels ［J］.Nucleic Acids Res, 1997, 25(21): 4296-4300 ［20］   Hastings M L,Ingle H A,Lazar M A, et al.Post-transcriptional regulation of thyroid hormone receptor expression by cis-acting sequences and a naturally occurring antisense RNA ［J］.J Biol Chem, 2000, 275(15): 11507-11513 ［21］   Peters N T,Rohrbach J A,Zalewski B A, et al.RNA editing and regulation of Drosophila 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts ［J］.RNA, 2003, 9(6): 698-710 ［22］   Ebralidze A K,Guibal F C,Steidl U, et al.PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element ［J］.Genes Dev, 2008, 22(15): 2085-2092 ［23］   Crampton N,Bonass W,Kirkham J, et al.Collision events between RNA polymerases in convergent transcription studied by atomic force microscopy ［J］.Nucleic Acids Res, 2006, 34(19): 5416-5425 ［24］   Osato N,Suzuki Y,Ikeo K, et al.Transcriptional interferences in cis natural antisense transcripts of humans and mice ［J］.Genetics, 2007, 176(2): 1299-1306 ［25］   Imamura T,Yamamoto S,Ohgane J, et al.Non-coding RNA directed DNA demethylation of Sphk1 CpG island ［J］.Biochem Biophys Res Commun, 2004, 322(2): 593-600 ［26］   Beltran M,Puig I,Pena C, et al.A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition ［J］.Genes Dev, 2008, 22(6):756-769 ［27］   Zhang K,Chen B,Wu G, et al.Molecular cloning and identification of naturally occurring human antisenseangiopoietin-1: Gna-1 ［J］.Sci China C Life Sci, 2001, 44(3): 314-320 ［28］   Morse D P,Aruscavage P J,Bass B L.RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNA ［J］.Proc Natl Acad Sci U S A, 2002, 99(12): 7906-7911 ［29］   Neeman Y,Dahary D,Levanon E Y, et al.Is there any sense in antisense editing? ［J］.Trends Genet, 2005, 21(10): 544-547 ［30］   Yu W,Gius D,Onyango P, et al.Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA ［J］.Nature, 2008, 451(7175): 202-206 ［31］   Watanabe T,Totoki Y,Toyoda A, et al.Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes ［J］.Nature, 2008, 453(7194): 539-543 ［32］   Faghihi MA,Zhang M,Huang J, et al.Evidence for natural antisense transcript-mediated inhibition of microRNA function ［J］.Genome Biol, 2010, 11(5): R56 ［33］   Lirk P,Hoffmann G,Rieder J.Inducible nitric oxide synthase--time for reappraisal ［J］.Curr Drug Targets Inflamm Allergy, 2002, 1(1): 89-108 ［34］   Matsui K,Nishizawa M,Ozaki T, et al.Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes ［J］.Hepatology, 2008, 47(2): 686-697 ［35］   Hatzoglou A,Deshayes F,Madry C, et al.Natural antisense RNA inhibits the expression of BCMA, a tumour necrosis factor receptor homologue ［J］.BMC Mol Biol, 2002, 3: 4 ［36］   Huang G,Zhang P,Hirai H, et al.PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis ［J］.Nat Genet, 2008, 40(1): 51-60 ［37］   Rosok O,Sioud M.Systematic identification of sense-antisense transcripts in mammalian cells ［J］.Nat Biotechnol, 2004, 22(1): 104-108 ［38］   Zhaohui Y,Xiaolin J,Xiancai R, et al.A novel strategy for systematic identification of natural antisense transcripts of Pseudomonas aeruginosa based on RNase I protection assay ［J］.Mol Biol (Mosk), 2007, 41(4): 640-646 ［39］   Zhang Y,Li J,Kong L, et al.NATsDB: Natural Antisense Transcripts DataBase ［J］.Nucleic Acids Res, 2007, 35(112): D156-161 ［40］   Yin Y,Zhao Y,Wang J, et al.antiCODE: a natural sense-antisense transcripts database ［J］.BMC Bioinformatics, 2007, 8: 319 ［41］   Li Y Y,Qin L,Guo Z M, et al.In silico discovery of human natural antisense transcripts ［J］.BMC Bioinformatics, 2006, 7(141): 18 ［42］   He S,Liu C,Skogerbo G, et al.NONCODE v2.0: decoding the non-coding ［J］.Nucleic Acids Res, 2008, 36(222): D170-172 ［43］   Grinchuk O V,Jenjaroenpun P,Orlov Y L, et al.Integrative analysis of the human cis-antisense gene pairs, miRNAs and their transcription regulation patterns ［J］.Nucleic Acids Res, 2010, 38(127): 534-547 ［44］   Conley A B,Miller W J,Jordan I K.Human cis natural antisense transcripts initiated by transposable elements ［J］.Trends Genet, 2008, 24(2): 53-56