朊蛋白PrPC与神经元的凋亡和存活

王朝云;田婵;董小平

中国生物化学与分子生物学报 ›› 2010, Vol. 26 ›› Issue (04) : 306-310.

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PDF(128 KB)
中国生物化学与分子生物学报 ›› 2010, Vol. 26 ›› Issue (04) : 306-310.
综述

朊蛋白PrPC与神经元的凋亡和存活

  • 王朝云;田 婵;董小平*
作者信息 +

Prion Protein in Neuron Apoptosis and Survival

  • WANG Zhao-Yun; TIAN Chan;DONG Xiao-Ping*
Author information +
文章历史 +

摘要

朊病毒是不含核酸的一种蛋白质感染颗粒,感染宿主后可诱导细胞固有的同类朊蛋白(PrPC)构象改变、转化成具有蛋白酶抗性的致病性朊粒蛋白(PrPSc),导致可传播性海绵状脑病的发生. PrPC既作为朊病毒复制和疾病发生的分子基础,又是正常的细胞膜蛋白,作为细胞信号转导的参与者调控多条信号通路.因此, 揭示PrPC在各条信号途径中发挥的作用将有助于深入了解PrPC的生理功能,进一步理解疾病发生发展过程,为今后的诊断治疗奠定基础.

Abstract

PrPSc is an infectious particle without nucleic acids, and the conformational alteration of the cellular prion protein(PrPC)to the form of insoluble and protease-resistant PrPSc leads to the transmissible spongiform encephalopathy. PrPC is a normal cell membrane protein, and plays an important role in the regulation of many signal pathways. Elucidating the physiologica functions of the PrPC in the infected cells is helpful to understand the molecular bases of occurrence and progression of the prion disease, and therefore provide the foundation for future diagnosis and treatment.

关键词

朊蛋白 / 信号通路 / 凋亡 / 氧化应激应答 / 神经毒性作用

Key words

Prion protein / signal pathway / apoptosis / oxidative stress response / neurotoxic effects

引用本文

导出引用
王朝云;田婵;董小平. 朊蛋白PrPC与神经元的凋亡和存活[J]. 中国生物化学与分子生物学报, 2010, 26(04): 306-310
WANGZhao-Yun;TIANChan;DONGXiao-Ping. Prion Protein in Neuron Apoptosis and Survival[J]. Chinese Journal of Biochemistry and Molecular Biology, 2010, 26(04): 306-310
中图分类号: R34   

参考文献

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