1　Zhang H,Kobayashi R,Galaktionov K,Beach D.p19Skp1and p45Skp2are essential elements of the cyclin A-CDK2S phase kinase.Cell,1995,82(6):915~925 2　Kornitzer D,Ciechanover A.Modes of regulation of ubiquitin-mediated protein degradation.J Cell Physiol,2000,182(1):1~11 3　DeSalle L M,Pagano M.Regulation of G1to S transition by the ubiquitin pathway.FEBSLett,2001,490(3):179~189 4　Yokoi S,Yasui K,Saito-Ohara F,Koshikawa K,Iizasa T,Fujisawa T,Terasaki T,Horii A,Takahashi T,Hirohashi S,Inazawa J.Anovel target gene,Skp2,within the5p13amplicon that is frequently detected in small cell lung cancers.AmJ Pathol,2002,161(1):207~216 5　Sana Y,Kohichiroh Y,Toshihiko I,Takashi T,Takehiko F,Johji I.Down-regulation of Skp2induces apoptosisinlung-cancer cells.Cancer Sci,2003,94(4):344~349 6　Lim MS,Adamson A,Lin Z,Perez-Oredonez B,Jordan R C,Tripp S,Perkins SL,Elenitoba-Johnson KS.Expression of Skp2,a p27(Kip1)ubiquitinligase,in malignant lymphoma:correlation with p27(Kip1)and proliferationindex.Blood,2002,100(8):2950~2956 7　Latres E,Chiarle R,Schulman B A,Pavletich NP,Pellicer A,Inghirami G,Pagano M.Role of the F-box protein Skp2inlymphomagenesis.Proc Natl Acad Sci USA,2001,98:2515~2520 8　钱俊杰,孙国敬,孟祥兵,宋宜,梅柱中,刘斌,董燕,孙志贤.HeLa细胞中Skp2的表达调控p21WAF/CIP1稳定性.中国生物化学与分子生物学报(Qian Jun-Jie,Sun Guo-Jing,Meng Xiang-Bin,Song Yi,Mei Zhu-Zhong,Liu Bin,Dong Yan,Sun Zhi-xian.Stability of p21WAF/CIP1regulated by Skp2in HeLa cells.Chin J Biochem Mol Biol),2004,20(6):732~737 9　宋宜,孟祥兵,梅柱中,刘斌,董燕,孙国敬,孙志贤.DNA损伤生物学反应中ATM对p21WAF/CIP1蛋白的直接磷酸化.中国生物化学与分子生物学报(Song Yi,Meng Xiang-Bin,Mei Zhu-Zhong,Liu Bin,Dong Yan,Sun Guo-Jing,Sun Zhi-Xian.Direct phosphorylation of p21WAF/CIP1with ATMin DNAdamage response.Chin J Biochem Mol Biol),2002,18(3):277~281 10　Lu L,Schulz H,Wolf D A.The F-box protein Skp2mediates androgen control of p27stability in LNCaP human prostate cancer cells.BMC Cell Biol,2002,3(1):22~34 11　Signoretti S,Di Marcotullio L,Richardson A,Ramaswamy S,Isaac B,Rue M,Monti F,Loda M,Pagano M.Oncogenic role of the ubiquitin ligase subunit Skp2in human breast cancer.J Clin Invest,2002,110(5):633~641 12　Nakayama K,Nagahama H,Minamishima Y A,Miyake S,Ishida N,Hatakeyama S,Kitagawa M,Iemura S,Natsume T,Nakayama KI.Skp2-mediated degradation of p27regulates progressioninto mitosis.Dev Cell,2004,6(5):661~672 13　Widlund HR,Horstmann MA,Price E R,Cui J,Lessnick S L,Wu M,He X,Fisher D E.Beta-catenin-induced melanoma growth requires the downstreamtarget Microphthalmia associated transcription factor.J Cell Biol,2002,158(6):1079~1087 14　Rossig L,Badorff C,Holzmann Y,Zeiher A M,Dimmeler S.Glycogen synthase kinase-3couples AKT-dependent signaling to the regulation of p21Cip1degradation.J Biol Chem,2002,277(12):9684~9689 15　Nalepa G,Wade Harper J.Therapeutic anti-cancer targets upstreamof the proteasome.Cancer Treat Rev,2003,29(1):49~57