RNA干涉的最新研究进展

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中国生物化学与分子生物学报 ›› 2003, Vol. 19 ›› Issue (04) : 411-417.

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RNA干涉的最新研究进展

吴元明,陈苏民

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Recent Advances in RNA Interference

WU Yuan\|ming, CHEN Su\|min *

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摘要

RNA干涉 (RNAi)是将双链RNA(dsRNA)导入细胞引起特异基因mRNA降解的一种细胞反应过程 .它是转录后基因沉默 (PTGS)的一种 .RNAi在生物界中广泛存在 .RNAi发生过程主要分为 3个阶段 :起始阶段 ,扩增阶段 ,效应阶段 .RNAi在维持基因组稳定、保护基因组免受外源核酸侵入、基因表达调控等方面发挥重要生物学作用 .RNAi作为基因沉默的一个工具 ,已被广泛用于基因功能研究、基因治疗和新药研究与开发等方面 .

Abstract

Introduction of double\|stranded RNA(dsRNA) into cells can induce specific mRNA degradation. This process is called RNA interference(RNAi). It is a kind of post\|transcriptional gene silencing(PTGS).RNAi exists in a wide variety of organisms. RNAi pathway can be divided into three steps: initiation step, amplification step and effector step. RNAi has important roles in maintaining the stabilization of the genome, protecting the genome from the invasion of the exogenic nucleic acid. As a gene silencing tool, RNAi has been widely used in gene function research,gene therapy and new drug research and development.

关键词

RNA干涉 / 转录后基因沉默 / 基因功能

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吴元明,陈苏民. RNA干涉的最新研究进展[J]. 中国生物化学与分子生物学报, 2003, 19(04): 411-417

WU Yuan\|ming, CHEN Su\|min *. Recent Advances in RNA Interference[J]. Chinese Journal of Biochemistry and Molecular Biology, 2003, 19(04): 411-417

参考文献

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收稿日期	修回日期	出版日期
2003-08-20	2003-08-20	2003-08-20
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2003-08-20

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