|
|
|
| MicroRNAs in the Pathogenesis of Atherosclerosis |
| REN Jing-Yi1), XU Ning2）, HAN Guan-Ping1）, CHENHong1）* |
(1) Department of Cardiology, Peking University Peoples Hospital, Beijing100044, China；
2) Department of Medicine, Karolinska Institute, Stockholm17176, Sweden) |
|
|
|
|
Abstract MicroRNAs (miRNAs) are short(～22 nt),noncoding RNAs that control gene expression on the posttranscriptional level by binding to target mRNA,leading to degradation or translation repression. miRNAs are involved in many biological processes under physiological and pathological conditions including cardiovascular diseases. Recent studies showed that miRNAs play an key role in the regulation of angiogenesis, inflammation and lipoprotein metabolism. miRNAs are closely related to atherosclerosis plaque destabilization and rupture. In this article, the research progress of miRNAs in the pathogenesis of atherosclerosis was reviewed to provide the basis for the study of the role of miRNAs in the pathogenesis of atherosclerosis and the application of miRNAs as a diagnostic tool for cardiovascular diseases.
|
|
Received: 10 December 2010
Published: 22 June 2011
|
|
|
|
Corresponding Authors:
Hong Chen
E-mail: chenhong0418@yahoo.com.cn
|
|
|
|
|
|
|
2011, Vol. 27 
