Insufficient folic acid supplementation during pregnancy can decrease the expression of histone demethylase KDM5A in fetal brain tissue. This in turn further mediates the downstream H3K4me3 modification to activate the expression of neurodevelopmental genes <em>Axin</em>2 and <em>Atoh</em>1, which results in fetal neural tube defects

Insufficient folic acid supplementation during pregnancy can decrease the expression of histone demethylase KDM5A in fetal brain tissue. This in turn further mediates the downstream H3K4me3 modification to activate the expression of neurodevelopmental genes Axin2 and Atoh1, which results in fetal neural tube defects

Cover picture designer　REN JiaXin, LI JianTing

Chinese Journal of Biochemistry and Molecular Biology ›› 2024, Vol. 40 ›› Issue (5) : 731.