Circadian Rhythm and Cell Cycle

Chinese Journal of Biochemistry and Molecular Biology ›› 2013, Vol. 29 ›› Issue (11) : 1010-1016.

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Chinese Journal of Biochemistry and Molecular Biology ›› 2013, Vol. 29 ›› Issue (11) : 1010-1016.
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Circadian Rhythm and Cell Cycle

  • XU Fei-Hong, BI Hai-Lian, WU Hui-Jian*
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Abstract

Circadian rhythm and cell cycle are the two main rhythmic and cyclical activities in living organisms, where expression of a series of genes to form a regulatory network. Recent studies have revealed that various clock rhythm factors controlled cell cycle procession by regulating the expression of cell cycle proteins. For examples,the activation of p21 by RORα leads to subsequent inhibition of G 1-S: transition; REV-ERBα interactions direct the inhibition of p21 to promote G1 phase progression; DEC1 inhibits cyclin D1; and BMAL1/CLOCK negatively regulates cmyc. G 2-M through Cry to activate Wee1 expression. The clock rhythm protein also involved in DNA damage repair and cell death by interacting with cell cycle factors. PER1 and TIM function as cofactors for the activation of ATM or ATR; Mutation of CRY in p53-null mice attenuates cancer onset, involving DEC1 is an effector downstream of p53 to promote premature senescence. The dysregulation of clock rhythm leads to or affects a variety of diseases, including tumors.

Key words

circadian rhythm / cell cycle / DNA damage repair / cell death

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Circadian Rhythm and Cell Cycle[J]. Chinese Journal of Biochemistry and Molecular Biology, 2013, 29(11): 1010-1016

References

1. Darlington TK, Wager-Smith K, Ceriani MF, et al. (1998) Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science 280: 1599-1603.

2. Hogenesch JB, Gu YZ, Jain S, et al. (1998) The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors. Proc Natl Acad Sci U S A 95: 5474-5479.

3. Gekakis N, Staknis D, Nguyen HB, et al. (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science 280: 1564-1569.

4. Preitner N, Damiola F, Lopez-Molina L, et al. (2002) The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110: 251-260.

5. Sato F, Kawamoto T, Fujimoto K, et al. (2004) Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1. Eur J Biochem 271: 4409-4419.

6. Zheng B, Albrecht U, Kaasik K, et al. (2001) Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 105: 683-694.

7. Hirayama J, Sahar S, Grimaldi B, et al. (2007) CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature 450: 1086-1090.

8. Sehgal A (2008) Ac-ing the clock. Neuron 57: 8-10.

9. Eide EJ, Kang H, Crapo S, et al. (2005) Casein kinase I in the mammalian circadian clock. Methods Enzymol 393: 408-418.

10. Lee C, Weaver DR, Reppert SM (2004) Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol 24: 584-594.

11. Gerard C, Goldbeter A (2009) Temporal self-organization of the cyclin/Cdk network driving the mammalian cell cycle. Proc Natl Acad Sci U S A 106: 21643-21648.

12. Bjarnason GA, Jordan RC, Wood PA, et al. (2001) Circadian expression of clock genes in human oral mucosa and skin: association with specific cell-cycle phases. Am J Pathol 158: 1793-1801.

13. Matsuo T, Yamaguchi S, Mitsui S, et al. (2003) Control mechanism of the circadian clock for timing of cell division in vivo. Science 302: 255-259.

14. Hunt T, Sassone-Corsi P (2007) Riding tandem: circadian clocks and the cell cycle. Cell 129: 461-464.

15. Borgs L, Beukelaers P, Vandenbosch R, et al. (2009) Cell "circadian" cycle: new role for mammalian core clock genes. Cell Cycle 8: 832-837.

16. Morf J, Schibler U (2010) Circadian cell-cycle progression: Cracking open the gate. Cell 140: 458-459.

17. Delaunay F, Laudet V (2002) Circadian clock and microarrays: mammalian genome gets rhythm. Trends Genet 18: 595-597.

18. Duffield GE (2003) DNA microarray analyses of circadian timing: the genomic basis of biological time. J Neuroendocrinol 15: 991-1002.

19. Sato TK, Panda S, Kay SA, et al. (2003) DNA arrays: applications and implications for circadian biology. J Biol Rhythms 18: 96-105.

20. Pines J (1999) Four-dimensional control of the cell cycle. Nat Cell Biol 1: E73-79.

21. Grechez-Cassiau A, Rayet B, Guillaumond F, et al. (2008) The circadian clock component BMAL1 is a critical regulator of p21WAF1/CIP1 expression and hepatocyte proliferation. J Biol Chem 283: 4535-4542.

22. Xu Q, Ma P, Hu C, et al. (2012) Overexpression of the DEC1 protein induces senescence in vitro and is related to better survival in esophageal squamous cell carcinoma. PLoS One 7: e41862.

23. Rothblum-Oviatt CJ, Ryan CE, Piwnica-Worms H (2001) 14-3-3 binding regulates catalytic activity of human Wee1 kinase. Cell Growth Differ 12: 581-589.

24. van der Horst GT, Muijtjens M, Kobayashi K, et al. (1999) Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature 398: 627-630.

25. Houtgraaf JH, Versmissen J, van der Giessen WJ (2006) A concise review of DNA damage checkpoints and repair in mammalian cells. Cardiovasc Revasc Med 7: 165-172.

26. Takai H, Tominaga K, Motoyama N, et al. (2000) Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. Genes Dev 14: 1439-1447.

27. Corellou F, Bisgrove SR, Kropf DL, et al. (2000) A S/M DNA replication checkpoint prevents nuclear and cytoplasmic events of cell division including centrosomal axis alignment and inhibits activation of cyclin-dependent kinase-like proteins in fucoid zygotes. Development 127: 1651-1660.

28. Kondratov RV, Antoch MP (2007) Circadian proteins in the regulation of cell cycle and genotoxic stress responses. Trends Cell Biol 17: 311-317.

29. Gery S, Komatsu N, Baldjyan L, et al. (2006) The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol Cell 22: 375-382.

30. Ozturk N, Lee JH, Gaddameedhi S, et al. (2009) Loss of cryptochrome reduces cancer risk in p53 mutant mice. Proc Natl Acad Sci U S A 106: 2841-2846.

31. Irwin MS, Kondo K, Marin MC, et al. (2003) Chemosensitivity linked to p73 function. Cancer Cell 3: 403-410.

32. Wang W, Kim SH, El-Deiry WS (2006) Small-molecule modulators of p53 family signaling and antitumor effects in p53-deficient human colon tumor xenografts. Proc Natl Acad Sci U S A 103: 11003-11008.

33. Tomasini R, Tsuchihara K, Wilhelm M, et al. (2008) TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev 22: 2677-2691.

34. Kawauchi K, Araki K, Tobiume K, et al. (2009) Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification. Proc Natl Acad Sci U S A 106: 3431-3436.

35. Sirotkin AV, Benco A, Tandlmajerova A, et al. (2008) Transcription factor p53 can regulate proliferation, apoptosis and secretory activity of luteinizing porcine ovarian granulosa cell cultured with and without ghrelin and FSH. Reproduction 136: 611-618.

36. Meylan E, Dooley AL, Feldser DM, et al. (2009) Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Nature 462: 104-107.

37. Hua H, Wang Y, Wan C, et al. (2006) Circadian gene mPer2 overexpression induces cancer cell apoptosis. Cancer Sci 97: 589-596.

38. Qian Y, Zhang J, Yan B, et al. (2008) DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J Biol Chem 283: 2896-2905.

Funding

Supported by National Natural Science Foundation of China (No. 31171353) and National Basic Research and Development Program of China (973 Program, No. 2011CB504201)

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