The Structure and Biological Functions of Sfi1p in Yeast Saccharomyces cerevisiae

PU Lin*

Chinese Journal of Biochemistry and Molecular Biology ›› 2012, Vol. 28 ›› Issue (7) : 587-592.

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PDF(378 KB)
Chinese Journal of Biochemistry and Molecular Biology ›› 2012, Vol. 28 ›› Issue (7) : 587-592.
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The Structure and Biological Functions of Sfi1p in Yeast Saccharomyces cerevisiae

  • PU Lin*
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Abstract

the microtubule organizing center of yeast cells, the spindle pole body (SPB) plays an important role in cell division and genome stability, therefore attracting a great attention and enormous research efforts on its physiological roles. In the yeast Saccharomyces cerevisiae, Sfi1p is an essential component of SPB, which localizes at half-bridge and spans its full length. Sfi1p, whose deletion or mutation causes a failure of SPB replication, is required for SPB duplication and self-assembly. A large number of studies show that Sfi1p has its homologous proteins in the mammalian centrosome. In this study, we reviewed the general structure of Sfi1p for both SPB in Saccharomyces cerevisiae and centrosome in human and elucidated the global function of Sfi1p involved in the cellular processes, including SPB duplication, separation, karyogamy and sporulation process. Studies on Sfi1p function will not only shed new light on our current understanding about yeast SPB structure and function, but also lay a foundation for investigation of its homologues in the mammalian centrosome.

Key words

spindle pole body (SPB) / Sfi1p / Half-Bridge

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PU Lin*. The Structure and Biological Functions of Sfi1p in Yeast Saccharomyces cerevisiae[J]. Chinese Journal of Biochemistry and Molecular Biology, 2012, 28(7): 587-592

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Funding

Supported  by  National Natural  Science  Foundation  of  China  (No.30771108/C0702)

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