MicroRNAs in the Pathogenesis of Atherosclerosis

REN Jing-Yi, XU Ning, HAN Guan-Ping, CHEN Hong

Chinese Journal of Biochemistry and Molecular Biology ›› 2011, Vol. 27 ›› Issue (6) : 511-515.

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PDF(226 KB)
Chinese Journal of Biochemistry and Molecular Biology ›› 2011, Vol. 27 ›› Issue (6) : 511-515.
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MicroRNAs in the Pathogenesis of Atherosclerosis

  • REN Jing-Yi1), XU Ning2), HAN Guan-Ping1), CHENHong1)*
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Abstract

MicroRNAs (miRNAs) are short(~22 nt),noncoding RNAs that control gene expression on the posttranscriptional level by binding to target mRNA,leading to degradation or translation repression. miRNAs are involved in many biological processes under physiological and pathological conditions including cardiovascular diseases. Recent studies showed that miRNAs play an key role in the regulation of angiogenesis, inflammation and lipoprotein metabolism. miRNAs are closely related to atherosclerosis plaque destabilization and rupture. In this article, the research progress of miRNAs in the pathogenesis of atherosclerosis was reviewed to provide the basis for the study of the role of miRNAs in the pathogenesis of atherosclerosis and the application of miRNAs as a diagnostic tool for cardiovascular diseases.

Key words

atherosclerosis / microRNAs / vascular endothelial function / inflammation / statins

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REN Jing-Yi, XU Ning, HAN Guan-Ping, CHEN Hong. MicroRNAs in the Pathogenesis of Atherosclerosis[J]. Chinese Journal of Biochemistry and Molecular Biology, 2011, 27(6): 511-515

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