The Role of TAR RNA Binding Protein in HIV-1 Infection

LIN Xiao-Yan, YANG Yi-Shu-*, ZENG Yi

Chinese Journal of Biochemistry and Molecular Biology ›› 2010, Vol. 26 ›› Issue (10) : 886-891.

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Chinese Journal of Biochemistry and Molecular Biology ›› 2010, Vol. 26 ›› Issue (10) : 886-891.
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The Role of TAR RNA Binding Protein in HIV-1 Infection

  • LIN Xiao-Yan, YANG Yi-Shu-*, ZENG Yi
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Abstract

Transactivation response RNA binding protein (TRBP), which binds to HIV-1 TAR RNA, belongs to the dsRNA binding protein family. TRBP promotes the expression of HIV-1 LTR by activating the basal transcription level of HIV-1 LTR or contributing to Tat-mediated transactivation. TRBP increases the efficiency of HIV-1 genes transcription and translation after binding to TAR RNA. TRBP is also a cellular protein linking the interferon anti-viral pathway and RNA interference pathway as an immune regulator. In interferon-induced PKR response, TRBP reverses the PKR inhibition of HIV-1 expression and production. TRBP acts as a cellular down-regulator of PKR by directly inhibiting PKR autophosphorylation, by competing for common RNA substrates with PKR, or by forming heterodimers with PACT. TRBP recruits the Dicer complex to Ago2 constituting the critical component of the RNA induced silencing complex (RISC), which is a key complex in the RNA interference pathway that controls the subsequent sequence-specific mRNA degradation. During HIV-1 infection, TRBP is prone to augment HIV-1 expression and replication, indicating that TRBP is a novel therapeutic target for controlling HIV-1 infection.

Key words

transactivation response RNA binding protein(TRBP) / protein kinase R(PKR) / human immunodeficiency virus type 1(HIV-1) / RNA interference(RNAi)

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LIN Xiao-Yan, YANG Yi-Shu-*, ZENG Yi. The Role of TAR RNA Binding Protein in HIV-1 Infection[J]. Chinese Journal of Biochemistry and Molecular Biology, 2010, 26(10): 886-891

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