Role of Vinculin in Cell Response to Mechanical Stimuli

HULi-Fang,QIANAi-Rong,SHANGPeng

Chinese Journal of Biochemistry and Molecular Biology ›› 2009, Vol. 25 ›› Issue (09) : 805-810.

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PDF(347 KB)
Chinese Journal of Biochemistry and Molecular Biology ›› 2009, Vol. 25 ›› Issue (09) : 805-810.
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Role of Vinculin in Cell Response to Mechanical Stimuli

  • HU Li-Fang, QIAN Ai-Rong, SHANG Peng*
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Abstract

Vinculin is a focal adhesion and cytoskeletal protein that distributed mainly at cell-cell junctions and cell-extracellular matrix (ECM) adhesions. Vinculin is involved in the mechano-chemical signal transmission of cells by binding to a variety of focal adhesion or cytoskeletal proteins, and plays important roles in cell adhesion, extension, motion, proliferation and survival. This review focuses on the molecular structure of vinculin and its role in the mechanotransduction.

Key words

vinculin / focal adhesion / cytoskeleton / mechanical stimuli / signal transduction

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HULi-Fang,QIANAi-Rong,SHANGPeng. Role of Vinculin in Cell Response to Mechanical Stimuli[J]. Chinese Journal of Biochemistry and Molecular Biology, 2009, 25(09): 805-810

References

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