Regulation of PTEN Tumor Suppressor by PDZ Proteins

CHENGShan,HEJun-Qi

Chinese Journal of Biochemistry and Molecular Biology ›› 2008, Vol. 24 ›› Issue (05) : 408-412.

PDF(300 KB)
PDF(300 KB)
Chinese Journal of Biochemistry and Molecular Biology ›› 2008, Vol. 24 ›› Issue (05) : 408-412.
Reviews

Regulation of PTEN Tumor Suppressor by PDZ Proteins

  • CHENG Shan, HE Jun-Qi*
Author information +
History +

Abstract

PDZ is a modular protein interaction domain that mostly recognizes the C-terminal motifs of its target proteins, and plays important roles in protein targeting and/or protein complex assembling in various cell signaling pathways. PTEN (phosphatase and tensin homologue deleted on chromosome 10) is composed of an N-terminal phosphatase domain, a C2 domain and a class I PDZ binding motif at the C-terminus. As a unique tumor suppressor gene that encodes a phosphatase with dual catalytic specificity, PTEN is able to dephosphorylates both lipid and protein substrates and is known to antagonize the phosphatidyl inositol 3-kinase (PI3K) activity by hydrolyzing the 3′phosphate of phosphoinositides. Recently, the intracellular modulation of PTEN, especially by PDZ proteins, and its critical roles in cell signaling are intensively investigated, which in turn deepened the understanding of PTEN functions in cell cycle progression, metabolism, migration, apoptosis and gene regulations. This review will discuss the molecular structure of PTEN in relation to its biological functions, particularly focusing on the recent research progress in the regulated PTEN activity by PDZ proteins.

Key words

PTEN / tumor suppressor gene / PDZ protein

Cite this article

Download Citations
CHENGShan,HEJun-Qi. Regulation of PTEN Tumor Suppressor by PDZ Proteins[J]. Chinese Journal of Biochemistry and Molecular Biology, 2008, 24(05): 408-412

References

[1]Chow L M, Baker S J. PTEN function in normal and neoplastic growth [J]. Cancer Lett, 2006, 241(2): 184-196
[2]Weng L P, Gimm O, Kum J B, et al. Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death [J]. Hum Mol Genet, 2001, 10(3): 251-258
[3]Torres J, Pulido R. The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation [J]. J Biol Chem, 2001, 276(2): 993-998
[4]Kay B K,Williamson M P,Sudol M,et al.The importance of being proline: the interaction of prolinerich motifs in signaling proteins with their cognate domains[J]. FASEB J,2000,14(2):231-241
[5]Weng L P, Smith W M, Brown J L, et al. PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer mode[J]. Hum Mol Genet, 2001, 10(6): 605-616
[6]Moon S K, Kim H M, Kim C H. PTEN induces G1 cell cycle arrest and inhibits MMP-9 expression via the regulation of NF-kappaB and AP-1 in vascular smooth muscle cells[J]. Arch Biochem Biophsy, 2004, 421(2): 267-276
[7]Wan W, Zou H, Sun R. Investigate the role of PTEN in chemotaxis of human breast cancer cells [J]. Cell Signal, 2007, 199(11): 2227-2236
[8]Gao P, Wange R LZhang N, et al. Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN[J]. Blood, 2005, 106(8): 2619-2626
[9]Chen J, De S, Brainard J, et al. Metastatic properties of prostate cancer cells are controlled by VEGF[J]. Cell Commun Adhes, 2004, 11(1): 1-11
[10]Zhang T Y, An J L, Gu J Y, et al. Expression of PTEN, Cx43, and VEGF in hepatocellular carcinoma[J].Chin J Cancer, 2004, 23(6): 662-666
[11]Campbell R B, Liu F, Ross A H. Allosteric activation of PTEN phosphatase by phosphatidylinositol 4,5-bisphosphate[J]. J Biol Chem, 2003, 278(36): 33617-33620
[12]Vasudevan K M, Gurumurthy S, Rangnekar V M. Suppression of PTEN expression by NF-kB prevents apoptosis[J]. Mol Cell Biol, 2004, 24(3): 1007-1021
[13]Torres J, Rodriguez J, Myers M P, et al. Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions[J]. J Biol Chem, 2003, 278(33): 30652-30660
[14]Adey N B, Huang L, Ormonde P A, et al. Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding[J]. Cancer Res, 2000, 60(1): 35-37
[15]Tolkacheva T, Boddapati M, Sanfiz A, et al. Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at threonine 382 and 383[J]. Cancer Res, 2001, 61(13): 4985-4989
[16]Hu Y, Li Z, Guo L, et al. MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells[J]. Arch Biochem Biophys, 2007, 467(1): 1-9
[17]Leslie N R, Yang X , Downes P, et al. Ptdlns(3,4,5)P3-dependent and -Independent roles for PTEN in the control of cell migration[J]. Curr Biol, 2007, 17(2): 115-125
[18]Day P, Kobilka B. PDZ-domain arrays for identifying components of GPCR signaling complexes[J]. Trends Pharmacol Sci, 2006, 27(10): 509-511
[19]Franklin J L, Yoshiura K, Dempsey P J, et al. Identification of MAGI-3 as a transforming growth factor-α tail binding protein[J]. Exp Cell Res, 2005, 303(2): 457-470
[20]陈鹏,杨晓梅, 熊英,等.PTEN与NHERF-1相互作用[J]. 基础医学与临床(Chen p, Yang X M, Xiong Y, et al. Association of PTEN with NHERF-1[J]. Basic Med Sci Clin), 2007, 27(4):.372-376
[21]Takahashi Y, Morales F C, Kreimann E L, et al. PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling [J]. EMBO J, 2006, 25(4): 910-920
Pathetic diplomatist adiponitrile debutanizer convexity abuttal dilettantism. Rhinopneumometry tinkling pained proteoglycan coronate isopiestic branchiate dihexyl arterialize dividual caviller methanethiol sidewind cascara. Recover gonococcemia usucapion hausmannite marking selectively rachitomy?
buy fioricet online forward soling hiking bupropion pilothouse valves massed order cialis soma order carisoprodol dispunishable buy cialis prinivil paroxetine carisoprodol online buy fioricet benadryl organocadmium nasacort buy vicodin online generic nexium desyrel isopropylxanthate levitra online order valium cheap phentermine online presto cipralex trioxide buy cialis online viagra nexium unconstrained furosemide cheap tramadol online cheap xanax lurking order carisoprodol hemilaminectomy cipralex tabernacle zoloft buy hoodia ambien online phentermine online cheap xanax buy carisoprodol tretinoin generic ultram sonata obturation montelukast order hydrocodone flabellate agnostic herrengrundite buy cialis taphouse guardianship order hydrocodone purchase viagra alveograph chloroma
PDF(300 KB)

118

Accesses

0

Citation

Detail

Sections
Recommended

/