1 　Shaw P C,Chan W L,Yeung H W ,Ng T B.Minireview :tri-chosanthin-a protein w ith m ultiple pharm acologicalproperties.Life Sci,1994,55:253～262 2 　Kahn JO,Gorelick K J,GattiG,ArriC J,Lifson JD,Gam ber-toglio JG,Bostrom A,W illiam s R.Safety,activity,and pharm a-cokinetics of GLQ223 in patients w ith AIDSand AIDS-relatedcom plex.Antim icrobiol Agents Chem other,1994,38:260～267 3 　Veronese F M ,Caliceti P,Schiavon O,Sartore L.Preparationand properties of m onom ethoxypoly(ethylene glycol)-m odifiedenzym es for therapeutic applications.In:Harris JM ed.Poly(ethylene glycol)Chem istry:Biotechnicaland Biom edical Appli-cations,New York:Plenum Press,1992:127～138 4 　Zalipsky S,Lee C.Use of functionalized poly(ethylene glycol)sfor m odification of polypeptides.In:Harris JM ed.Poly(ethy-lene glycol) Chem istry: Biotechnical and Biom edical Applica-tions,New York:Plenum Press,1999:347～370 5 　Chan W L,Shaw P C,LiX B,Xu Q F,He X H,Tam S C.Low -ering of trichosanthin im m unogenicity by site-specific couplingto dextran.Biochem Pharm acol,1998,57:927-934 6 　何贤辉,柯一保,蔡迎春,聂慧玲.天花粉蛋白Lys 和Arg 残基的化学修饰对其与IgE 反应活性的影响.生物化学与生物物理学报(He Xianhui,Ke Yibao,CaiYingchun,Nie Huiling.Effectsof chem ical m odification of lysine and argnine residues of tri-chosanthin of its reactivity w ith IgE. Acta Biochim BiophysSin),1994,26:657～662 7 　Pelham H R B, Jackson R J. An efficient m RNA-dependenttranslation system from reticulocyte lysates.Eur J Biochem ,1976,67:247～256 8 　Ko W H,Yeung H W ,Tam SC.The biologicalactivities of tri-chosanthin after coupling to dextran.Gen Pharm acol,1993,24:757～762 9 　Ke Y B,W ang Y H,Yao Z,W ang K M .Antigenic determ inantof trichosanthin peptide fragm ents.Im m unopharm acol Im m uno-toxicol,1988,10:131～139 10　Lee A C J,Pow ellJE,Tregear G W ,NiallH D,Stevens V C.Am ethod for preparing β-hCG COOH peptide-carrier conjugatesofpredictable com position.M olIm m unol,1980,17:747～756 11　高奔,马星奇,王耀萍,陈世芝,吴伸,董贻诚.天花粉蛋白1.73埃分辨率结构的精化.中国科学,B辑(Gao Ben,M a Xingqi,W angYaoping,Chen Shizhi,W u Shen,Dong Yicheng.Refined struc-ture oftrichosanthin at 1.73 A resolution.SciChina,Series B),1994,24:48～56 12　Clark R,Olson K,Fuh G,Marian M ,Mortensen D,Teshim a G,Chang S,Chu H,Mukku V,Canova-Davis E,Som ers T,CroninM ,W inkler M ,W ells JA.Long-acting grow th horm ones pro-duced by conjugation w ith polyethylene glycol.J Biol Chem ,1996,271:21969～21977 13　袁惠东,李默漪,邵晓霞,崔大敷,夏其昌,张祖传.抗天花粉蛋白单抗T8C12 针对的抗原表位的判定.生物化学与生物物理学报(Yuan Huidong,LiM oyi,Shao Xiaoxia,CuiDafu,Xia Qichang,Zhang Zuchuan.Determ ination of the binding epitope forantitri-chosanthin m onoclonal antibody T8 C12. Acta Biochim BiophysSin),1998,30:137～141