Exosomal Circular RNAs Mediates Chemotherapy Resistance in Tumors
GENG Xiu-Chao1),2),3), LI Qiang1),4)*, WANG Hong2),3),5)
1)School of Medicine, Taizhou University, Taizhou 318000, Zhejiang, China; 2)Faculty of Integrated Traditional Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050200, China; 3)Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Hebei Province, Shijiazhuang 050091, China; 4)Faculty of Acupuncture-Moxibustion and Tuina, Hebei University of Chinese Medicine, Shijiazhuang 050200, China; 5)Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding 071000, Hebei, China
Abstract：As an important member of the non-coding RNA family, circRNA is a kind of single-stranded RNA with a covalently closed loop structure without a polyadenylated acid tail and 5′-3′ end, showing high stability, abundance and conservation across species characteristics. Recent studies have shown that circRNA plays an important role in many biological processes, including chemotherapy resistance and malignant progression. Exosomes are small extracellular phospholipid bilayer vesicles with a diameter of 30-150 nm that are secreted by living cells. They can be used as carriers to encapsulate and transfer functional molecules. Exosomes are important mediators of communication between tumor cells and stromal cells. They can play a role in the transmission of chemoresistance by transferring circRNA. As chemotherapy resistance is still a huge obstacle to the prognosis of cancer, the research of exosomal circRNA-mediated tumor chemotherapy resistance is at the forefront of academic research, which is a blue ocean with important significance. In this paper, we summarized the latest research progress in the aspects of exosome delivery of circRNA, the mechanism of exosome sorting non-coding RNA cargo, circRNA-mediated tumor chemotherapy resistance, exosome delivery of circRNA-mediated tumor chemotherapy resistance and its potential clinical application, which may provide a reference for the research of tumor chemotherapy resistance.
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