The Influence of Environmental Factors on Transgenerational Transmission Mediated by Sperm sncRNAs
HUA Min-Min1), SHI Hui-Juan1), RU Yan-Fei2)*
1)NHC Key Lab of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), Fudan University, Shanghai 200032, China; 2)Zhejiang Provincial Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province/Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou 310024, Zhejiang, China
Abstract：Developmental programming of the embryo is controlled by both genetic information and epigenetic information. During fertilization, this information carried by sperms can be delivered to the zygote, where they can regulate early embryonic development. Mature sperms are highly abundant in epigenetic information, and including small non-coding RNAs (sncRNAs), which play important roles during spermatogenesis, fertilization, and early embryo development. Recent studies revealed that sncRNAs can regulate gene expression, mediate protein translation, transmit the epigenetic information, and so on. Recently, increasing evidences showed that parental environment exposure, such as diet, toxicant, pressure, may cause the inheritance of acquired characteristics, and they can be stored and transmitted to the next generation by epigenetic information in germ cells. Recent advances of transgenerational inheritance revealed that sncRNAs are environmentally responsive epigenetic molecules in sperms. This review summarized current knowledge about the sncRNAs information in sperms, including transfer RNA-derived small RNAs (tsRNAs), rsRNAs (risbosome-RNA derived small RNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), that are responsive to environmental factors and are capable of affecting embryonic development and the phenotype of the offspring later in life. Furthermore, this review also delineated potential molecular mechanisms that might regulate sperm sncRNAs.
华敏敏, 施惠娟, 茹彦飞. 精子sncRNAs在环境暴露相关跨代遗传中的作用[J]. 中国生物化学与分子生物学报, 2022, 38(2): 127-136.
HUA Min-Min, SHI Hui-Juan, RU Yan-Fei. The Influence of Environmental Factors on Transgenerational Transmission Mediated by Sperm sncRNAs. Chinese Journal of Biochemistry and Molecular Biol, 2022, 38(2): 127-136.
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