The Anti-tumor Nano-drug Carrier System Modified by the Nuclear Localization Signal Peptide
LI Ruo-Jin1), WU Xiao-Xue1), WANG Che1),2)*
1)College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, Liaoning, China; 2)Liaoning Key Laboratory of Biotechnology and Molecular Drug Development, Dalian 116081, Liaoning, China
Abstract：Nano-drug carrier systems, as the controllable and targeting tool to deliver drugs, can effectively improve the drug bioavailability, enhance their therapeutic outcomes and reduce side effects, mainly through protecting drugs from rapid enzymatic degradation and blood clearance and ensuring them to be delivered to the targeting sites. The nano-drug carrier system owns broad application prospects in the biomedical field and attracts increasing attention in both functional materials and anti-tumor research. Recently, functional surface modification with functional biomolecules to improve the biocompatibility and drug bioactivity is a hot topic in nano medicine research. The nucleus is the main site of action for many anti-tumor substances. And nuclear localization signal (NLS) peptides, as a type of functional peptides with nuclear-targeting activity, can penetrate through biological membranes and target the nucleus and is considered to be a universal tool for constructing nano-drug carrier systems. The use of NLS peptides to construct a functionalized nano-drug carrier system with nuclear targeting ability has important application values in the field of anti-tumor therapy. Although the synthesis process of nuclear-targeted functionalized nano-drug carrier system has been developed, due to the high preparation cost and complex synthesis process, there is still a long research process in the successful translation of nuclear-targeted nanocarriers from the experimental stage to the clinical stage. This review mainly focuses on the composition and construction of the nuclear-targeted functionalized nano-drug carrier system, analyzes its nuclear entry methods and conditions, and prospects the development of the anti-tumor nano-drug carrier system in the future based on the current challenges.
李若瑾, 吴晓雪, 王澈. 核定位信号肽修饰的抗肿瘤纳米载药体系[J]. 中国生物化学与分子生物学报, 2022, 38(1): 35-41.
LI Ruo-Jin, WU Xiao-Xue, WANG Che. The Anti-tumor Nano-drug Carrier System Modified by the Nuclear Localization Signal Peptide. Chinese Journal of Biochemistry and Molecular Biol, 2022, 38(1): 35-41.
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