Circular RNA CDR1as: A Novel Regulator of Malignant Tumors
ZHANG Han1), LI Xing1), HAN Peng-Fei2)*
1)Mudanjiang Medical University, First Clinical Medical School, Mudanjiang 157011, Heilongjiang, China; 2)Laboratory of Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang 157011, Heilongjiang, China
Abstract：Circular RNA (circRNA) is a new type of non-coding RNA with closed circular structures that are widely distributed in various tissues. Compared with traditional linear RNA, circRNA does not have 5′ and 3′ ends and will not be easily degraded by exonuclease. It can stably exist in a variety of body fluids and is evolutionarily conserved. It has become a key research object of clinical non-coding RNA. Malignant tumors have the characteristics of late detection, rapid progression, and easy recurrence. Currently, effective treatment methods are lacking, and their morbidity and mortality have been high. Therefore, how to carry out early diagnosis, treatment intervention and prognosis evaluation is one of the research frontier of contemporary medical research. CDR1as is the most widely studied circRNA. It can regulate the expression of downstream genes through sponge microRNA (miRNA) or directly bind to RNA-binding proteins (RBPs) to activate related signaling pathways, thereby promoting or inhibiting tumor progression, and even affecting tumor chemotherapy sensitivity. CDR1as mainly exists in the cytoplasm and can be released into the blood at the early stage of the disease. Therefore, CDR1as may become a biomarker for early diagnosis of malignant tumors or an ideal target for therapeutic intervention. Focusing on the characteristics and biological functions of circRNA, this article reviews the expression level, mechanism of action and related signaling pathways of CDR1as in the occurrence and development of malignant tumors. At the same time, this article analyzes the current research status of CDR1as, preliminarily summarizes the problems it may face in clinical applications in the future, and puts forward ideas and suggestions on the future research direction of CDR1as.
张晗, 李兴, 韩鹏飞. 环状RNA CDR1as:恶性肿瘤的新型调控因子[J]. 中国生物化学与分子生物学报, 2021, 37(10): 1329-1335.
ZHANG Han, LI Xing, HAN Peng-Fei. Circular RNA CDR1as: A Novel Regulator of Malignant Tumors. Chinese Journal of Biochemistry and Molecular Biol, 2021, 37(10): 1329-1335.
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