The Role and Mechanism of Exosomes in Exercise Cardiovascular Protection
PU Rui1),2), CHEN Zi-Yang1),2), YUAN Ling-Yan2)*
1)College of Education and Sports Sciences, Yangtze University, Hubei Jingzhou 434023, China; 2)Department of Human Movement Sciences, Institute of Physical Education, Shanghai Normal University, Shanghai 200234, China
Abstract：Exosome is a kind of vesicular body which can be secreted by most cells and can communicate information between cells through the transfer of specific signal molecules. More and more studies have shown that exosomes are widely involved in the occurrence and development of cardiovascular diseases, such as hypertension, heart failure and myocardial infarction. In recent years, studies have shown that exercise has a great impact on the biological function of body fluids and blood circulation exosomes. Different exercise modes can promote the release of exosomes and affect the expression of miRNA and proteins. At present, studies have found that exercise promotion of exosome release may be related to the laminar shear force induced by blood flow, the increase of Ca+ levels, the signal transduction between various cells during exercise and the activation of body physiological states, but the mechanism of exercise promotion of exosome release still needs to be improved. In addition, the release of exosomes and changes in their contents are also considered to be markers of adaptive changes in the body. Recent studies have shown that exercise promotes the release of exosomes and regulates the expression of miRNAs and proteins, thus playing key roles in promoting angiogenesis, inhibiting myocardial apoptosis, inhibiting myocardial fibrosis and protecting endothelial cells, providing a theoretical basis for the prevention and treatment of cardiovascular diseases. Herein the role of exosomes from different cell sources in cardiovascular diseases is reviewed in this paper. We analyze the regulation of exercise exosomes and the molecular mechanism of exercise regulation exosomes in cardiovascular protection, aiming to provide new ideas for the prevention and treatment of cardiovascular diseases.
蒲锐, 陈子扬, 袁凌燕. 外泌体在运动心血管保护中的作用及机制[J]. 中国生物化学与分子生物学报, 2021, 37(9): 1145-1154.
PU Rui, CHEN Zi-Yang, YUAN Ling-Yan. The Role and Mechanism of Exosomes in Exercise Cardiovascular Protection. Chinese Journal of Biochemistry and Molecular Biol, 2021, 37(9): 1145-1154.
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