Effects of Competing Endogenous RNA on Proliferation and Differentiation of Skeletal Muscle Cells
DU Tian-Ning, LIU Jie-Ming, SHI Xin-E*
Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China
Abstract：The skeletal muscle is an important part of the animal body, which is closely related to body movement, energy consumption, production performance and its development process is regulated by many factors. The molecular mechanism of skeletal muscle growth and development is not only closely related to animal husbandry production, but also provides a theoretical basis for the treatment of muscle diseases, such as amyotrophic muscular dystrophy, and so on. Non-coding RNA (ncRNA) is a kind of RNA without coding ability, in which circular RNA (circRNA), long non-coding RNA (lncRNA) and micro RNA (miRNA) have been proved to play an important role in the development of skeletal muscles. miRNA can specifically bind to the 3′ untranslated region (3′ UTR) of the target gene through its seed sequence, so as to inhibit the translation process of the target gene or directly degrade the target gene, and become a prominent participant in a variety of biological processes. Studies have shown that circRNA, lncRNA, pseudogenes and mRNA with miRNA response elements (MRE) can competitively combine miRNA to regulate gene expression, forming a competing endogenous RNA (ceRNA) regulatory network model. This hypothesis subverts the previous concept of unidirectional regulation of target genes by miRNA, and endows them with new biological functions in transcriptome, which is of great biological significance. In recent years, it has been found that ceRNA plays an important regulatory role in the growth and development of skeletal muscles. This paper reviews the role of miRNA, lncRNA and circRNA in the proliferation and differentiation of animal skeletal muscle cells, which is an important member of ceRNA mechanism, in order to broaden the research direction of skeletal muscle mechanism and provide new ideas for the development of animal husbandry and the treatment of muscle diseases.
杜天宁, 刘捷明, 史新娥. 竞争性内源RNA在骨骼肌细胞增殖分化中的作用[J]. 中国生物化学与分子生物学报, 2021, 37(9): 1131-1137.
DU Tian-Ning, LIU Jie-Ming, SHI Xin-E. Effects of Competing Endogenous RNA on Proliferation and Differentiation of Skeletal Muscle Cells. Chinese Journal of Biochemistry and Molecular Biol, 2021, 37(9): 1131-1137.
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