Abstract：The prevalence of obesity has been rising in recent years. Obesity has become one of the global public health problems, which can increase the risk of hypertension, coronary heart disease and other cardiovascular diseases, and prevention and treatment of obesity has become an urgent social problem to be solved. Beige adipocytes are new kind of heat-producing adipocytes, which can be transformed by white adipocytes stimulated by chronic cold exposure, some medicine and exercise. The morphology and function of beige adipocytes are different from white adipocytes, but are similar to brown adipocytes. Beige adipocytes have abundant mitochondria and can produce heat to consumer energy, which are new target for the prevention and treatment of obesity. Mitochondria is the main part of energy metabolism in eukaryotic cells, which can provide energy to the body. Mitochondrial quality control regulates mitochondrial quantity and quality in beige adipocytes, which can affect the conversion and thermogenesis of beige adipocytes. Mitochondrial quality control is regulated by several coordinated mechanisms including mitochondrial biogenesis, mitophagy and fission/fusion. The mitochondrial biogenesis and mitophagy can regulate mitochondrial renewal and degradation, and the mitochondrial fusion/division is responsible for mitochondrial repairing. Some studies have found that the change of mitochondrial quantity, morphology and function can affect the beige adipocytes formation, beige adipocytes maintenance and thermogenesis. However, the relationship between mitochondrial quality control and beige adipocytes remains unclear. In this review, we discuss the effect of mitochondrial biogenesis，mitophagy and mitochondrial fission/fusion on beige adipocytes, and illustrate the relationship between mitochondrial quality control and beige adipocytes, which may provide new insights into the prevention and treatment of obesity.
林翠，秦虹. 线粒体质量控制与米色脂肪之间的关系[J]. 中国生物化学与分子生物学报, 2021, 37(3): 316-320.
LIN Cui， QIN Hong. The Relationship Between Mitochondrial Quality Control and Beige Adipocytes. Chinese Journal of Biochemistry and Molecular Biol, 2021, 37(3): 316-320.
[1]Palikaras K, Lionaki E, Tavernarakis N.Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis[J].Cell Death Differ, 2015, 22(9):1399-1401
[2]FernándezGalilea M, PérezMatute P, PrietoHontoria PL, et al.alphaLipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweightobese subjects[J].Biochim Biophys Acta, 2015, 1851(3):273-281
[3]Mooli RGR, Mukhi D, Watt M, et al.Sustained mitochondrial biogenesis is essential to maintain caloric restrictioninduced beige adipocytes ［J］. Metabolism, 2020, 107:154225
[4]AltshulerKeylin S, Shinoda K, Hasegawa Y, et al.Beige adipocyte maintenance is regulated by autophagyinduced mitochondrial clearance[J].Cell Metab, 2016, 24(3):402-419
[5]Lee JH, Park A, Oh KJ, et al.The role of adipose tissue mitochondria: regulation of mitochondrial function for the treatment of metabolic diseases[J].Int J Mol Sci, 2019, 20(19):4924-
[6]Finlin BS, Memetimin H, Confides AL, et al.Human adipose beiging in response to cold and mirabegron[J].JCI Insight, 2018, 3(15):e121510-
[7]Garcia RA, Roemmich JN, Claycombe KJ.Evaluation of markers of beige adipocytes in white adipose tissue of the mouse ［J］. Nutr Metab (Lond), 2016, 13:24
[8]Porter C.Quantification of UCP1 function in human brown adipose tissue[J].Adipocyte, 2017, 6(2):167-174
[9]Li L, Li B, Li M, et al.Switching on the furnace: Regulation of heat production in brown adipose tissue ［J］. Mol Aspects Med, 2019, 68:6073
[10]Palikaras K, Tavernarakis N.Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis ［J］. Exp Gerontol, 2014, 56:182188
[11]Islam H, Edgett BA, Gurd BJ.Coordination of mitochondrial biogenesis by PGC1α in human skeletal muscle: A reevaluation ［J］. Metabolism, 2018, 79: 4251
[12]Li PA, Hou X, Hao S.Mitochondrial biogenesis in neurodegeneration[J].J Neurosci Res, 2017, 95(10):2025-2029
[13]Yoshioka K, Fujita R, Seko D, et al.Distinct roles of Zmynd17 and PGC1alpha in mitochondrial quality control and biogenesis in skeletal muscle ［J］. Front Cell Dev Biol, 2019, 7:330
[14]Peng K, Yang L, Wang J, et al.The interaction of mitochondrial biogenesis and fissionfusion mediated by PGC1α regulates rotenoneinduced dopaminergic neurotoxicity[J].Mol Neurobiol, 2017, 54(5):3783-3797
[15]Lee CC, Shih YC, Kang ML, et al.Naa10p inhibits beige adipocytemediated thermogenesis through Nαacetylation of Pgc1α[J].Mol Cell, 2019, 76(3):500-515
[16]Liu M, Zheng M, Cai D, et al.Zeaxanthin promotes mitochondrial biogenesis and adipocyte browning via AMPKα1 activation[J].Food Funct, 2019, 10(4):2221-2233
[17]Lemecha M, Morino K, Imamura T, et al.MiR4943p regulates mitochondrial biogenesis and thermogenesis through PGC1α signalling in beige adipocytes[J].Sci Rep, 2018, 8(1):15096-
[18]Laiglesia LM, LorenteCebriána S, PrietoHontoria PL, et al.Eicosapentaenoic acid promotes mitochondrial biogenesis and beigelike features in subcutaneous adipocytes from overweight subjects ［J］. J Nutr Biochem, 2016, 37:7682
[19]Heo JM, Ordureau A, Paulo JA, et al.The PINK1PARKIN mitochondrial ubiquitylation pathway drives a program of OPTNNDP52 recruitment and TBK1 activation to promote mitophagy[J].Mol Cell, 2015, 60(1):7-20
[20]Ivankovic D, Chau KY, Schapira AHV, et al.Mitochondrial and lysosomal biogenesis are activated following PINK1parkinmediated mitophagy[J].J Neurochem, 2016, 136(2):388-402
[21]Taylor D, Gottlieb RA.Parkinmediated mitophagy is downregulated in browning of white adipose tissue[J].Obesity (Silver Spring), 2017, 25(4):704-712
[22]Sarraf S A, Youle RJ.Parkin mediates mitophagy during beigetowhite fat conversion[J].Sci Signal, 2018, 11(527):e-a
[23]Xie S, Li Y, Teng W, et al.Liensinine inhibits beige adipocytes recovering to white adipocytes through blocking mitophagy flux in vitro and in vivo[J].Nutrients, 2019, 11(7):1640-
[24]Lu X, AltshulerKeylin S, Wang Q, et al.Mitophagy controls beige adipocyte maintenance through a Parkindependent and UCP1independent mechanism[J].Sci Signal, 2018, 11(527):e-a
[25]Lee H, Yoon Y.Mitochondrial fission and fusion[J].Biochem Soc Trans, 2016, 44(6):1725-1735
[26]Tahrir FG, Langford D, Amini S, et al.Mitochondrial quality control in cardiac cells: Mechanisms and role in cardiac cell injury and disease[J].J Cell Physiol, 2019, 234(6):8122-8133
[27]Silva Ramos E, Motori E, Brüser C, et al.Mitochondrial fusion is required for regulation of mitochondrial DNA replication[J].PLoS Genet, 2019, 15(6):e1008085-
[28]Anzell AR, Maizy R, Przyklenk K, et al.Mitochondrial quality control and disease: insights into ischemiareperfusion injury[J].Mol Neurobiol, 2018, 55(3):2547-2564
[29]Wang R, Wang G.Autophagy in mitochondrial quality control［J］.Adv Exp Med Biol, 2019, 1206:421434
[30]VásquezTrincado C, GarcíaCarvajal I, Pennanen C, et al.Mitochondrial dynamics,mitophagy and cardiovascular disease[J].J Physiol, 2016, 594(3):509-525
[31]Zhang Z, Liu L, Wu S, et al.Drp1,Mff,Fis1,and MiD51 are coordinated to mediate mitochondrial fission during UV irradiationinduced apoptosis[J].FASEB J, 2016, 30(1):466-476
[32]Hu C, Huang Y, Li L.Drp1dependent mitochondrial fission plays critical roles in physiological and pathological progresses in mammals[J].Int J Mol Sci, 2017, 18(1):144-
[33]Wikstrom JD, Mahdaviani K, Liesa M, et al.Hormoneinduced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure[J].EMBO J, 2014, 33(5):418-436
[34]VelazquezVillegas LA, Perino A, Lemos V, et al.TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue[J].Nat Commun, 2018, 9(1):245-
[35]Pisani DF, Barquissau V, Chambard JC, et al.Mitochondrial fission is associated with UCP1 activity in human brite/beige adipocytes ［J］. Mol Metab, 2018, 7: 3544
