Opposite Expression of HNRNPA2B1 in Cancer and Senescent Cells and Its Regulatory Role in Senescence of Cancer Cells
CAO Jun-Hong1), CHEN Meng2), JIA Qi1), ZHAO Zhao-Zhao1), WEN Hai-Mei1), YAO Jun1), YU Peng1), MA Hai-Jing1), NI Ting1)*, WEI Gang1)*
(1)Ministry of Education (MOE) Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development,Human Phenome Institute, School of Life Sciences, Fudan University, Shanghai 200438, China;2) Eye Institute, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China)
Splicing factor Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1) is associated with mouse lifespan and human longevity. It also plays a causal role in cancer development. However, whether it participates in cellular senescence, a biological process that contributes to individual aging and inhibits cancer, remains unknown. Here, we report that HNRNPA2B1 showed significantly increased expression in various cancer types while consistently decreased expression in multiple cellular senescence models. Knocking down HNRNPA2B1 in cancer cells leads to a series of senescence-associated phenotypes. In line with its function as a splicing factor, HNRNPA2B1 downregulation causes alternative splicing changes in over one thousand genes, including those known to have a causal role in senescence. Our results also suggests that the E2F transcription factor 1 (E2F1) could regulate the expression of HNRNPA2B1, and E2F1-HNRNPA2B1 may be a new regulatory axis functioning in both cancer and cellular senescence, which might also have potential medical implications for cancer therapies.
曹君红, 陈蒙, 贾琦, 赵昭昭, 文海梅, 姚钧, 余鹏, 马海静, 倪挺, 魏刚. 剪接因子异质核糖核蛋白A2B1在癌细胞和衰老细胞中的相反表达趋势及其对癌细胞衰老的调控[J]. 中国生物化学与分子生物学报, 2021, 37(1): 66-75.
CAO Jun-Hong, CHEN Meng, JIA Qi, ZHAO Zhao-Zhao, WEN Hai-Mei, YAO Jun, YU Peng, MA Hai-Jing, NI Ting, WEI Gang. Opposite Expression of HNRNPA2B1 in Cancer and Senescent Cells and Its Regulatory Role in Senescence of Cancer Cells. Chinese Journal of Biochemistry and Molecular Biol, 2021, 37(1): 66-75.
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