(1)Institute of Neurology, Guangdong Key Laboratory of Agerelated Cardiaccerebral Vascular Disease, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong, China;2) College of Life Sciences, Hunan Normal University, Changsha 410081, China)
Abstract：Autophagy is a major pathway for the degradation of large protein aggregates and damaged organelles in autolysosomes. Yet the important role of autophagy in intracellular homeostasis, material balance, embryonic development and the occurrence of diseases is well recognized, the formation of autophagosome as a double-membrane structure remained far from clear. Recently, rapid progress to elucidate molecular basis for autophagosome assembling revealed the importance of several participating tracellular organelles, including endoplasmic reticulum, Golgi apparatus, endosomes, plasma membrane and mitochondria for supplying membrane constituents. Here we summarized most recent research advances to address the origin of autophagosome membrane.
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