Abstract:Atherosclerosis is a chronic disease of larger and medium size arteries that endangers human health. The pathogenesis of this disease has been studied and significant progress was made with the advances of epigenetics, including the implement of Human Epigenome Project supervised by the international human epigenome Association. As the mechanism of DNA methylation and miRNA function have been better and better understood, the increasing evidence from atherosclerosis studies can be used as independent evaluation factors not only, but also help to understand the interaction and regulation network in the disease development. In this review, we focus on the latest reports upon the interplay of DNA methylation and miRNA regulation in atherosclerosis.
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