Abstract：Atherosclerosis is a chronic disease of larger and medium size arteries that endangers human health. The pathogenesis of this disease has been studied and significant progress was made with the advances of epigenetics, including the implement of Human Epigenome Project supervised by the international human epigenome Association. As the mechanism of DNA methylation and miRNA function have been better and better understood, the increasing evidence from atherosclerosis studies can be used as independent evaluation factors not only, but also help to understand the interaction and regulation network in the disease development. In this review, we focus on the latest reports upon the interplay of DNA methylation and miRNA regulation in atherosclerosis.
张海 张凯 王佐. DNA甲基化与miRNA相互调节与动脉粥样硬化[J]. 中国生物化学与分子生物学报, 2014, 30(10): 985-992.
ZHANG Hai, ZHANG Kai, WANG Zuo. The Regulation Network of DNA Methylation and miRNA in Atherosclerosis. Chinese Journal of Biochemistry and Molecular Biol, 2014, 30(10): 985-992.
Singh M, Bedi U S.Is atherosclerosis regression a realistic goal of statin therapy and what does that mean?[J].Curr Atheroscler Rep, 2013, 15(1):294-307
Chen X N, Pan X X, Yu H J, et al.Analysis of cardiovascular disease in Chinese inpatients with chronic kidney disease[J].Intern Med, 2011, 50(17):1797-1801
Lewis S J.Prevention and treatment of atherosclerosis: a practitioner's guide for 2008[J].Am J Med, 2009, 122(1 Suppl):S38-S50
Arend N, Hilgers K F, Campean V, et al.Darbepoetin alpha reduces oxidative stress and chronic inflammation in atherosclerotic lesions of apoE deficient mice in experimental renal failure[J].PLoS One, 2014, 9(2):e88601-e88613
Makowski M R, Botnar R M.MR imaging of the arterial vessel wall: molecular imaging from bench to bedside[J].Radiology, 2013, 269(1):34-51
Wolf D, Stachon P, Bode C, et al.Inflammatory mechanisms in atherosclerosis[J].Hamostaseologie, 2014, 34(1):63-71
Andres G, Ashour N, Sánchez-Chapado M, et al.The study of DNA methylation in urological cancer: present and future[J].Actas Urol Esp, 2013, 37(6):368-375
Zaina S.Unraveling the DNA methylome of atherosclerosis[J].Curr Opin Lipidol, 2014, 25(2):148-153
Crider K S, Yang T P, Berry R J, et al.Folate and DNA Methylation: A Review of Molecular Mechanisms and the Evidence for Folate，s role[J].Adv Nutr, 2012, 3(1):21-38
Kikuyama M, Takeshima H, Kinoshita T, et al.Development of a novel approach,the epigenome-based outlier approach,to identify tumor-suppressor genes silenced by aberrant DNA methylation[J].Cancer Lett, 2012, 322(2):204-212
Stenvinke P, Karimi M, Johansson S, et al.Impact of inflammation on epigenetic DNA methylation - a novel risk factor for cardiovascular disease?[J].J Intern Med, 2007, 261(5):488-499
Schleithoff C, Voelter-Mahlknecht S, Dahmke I N, et al.On the epigenetics of vascular regulation and disease[J].Clin Epigenetics, 2012, 4(1):7-20
Dong C, Yoon W, Goldsehmidt-Clermont P J.DNA methylation and atherosclerosis[J].J Nutr, 2002, 132(8 Suppl):2406-S
Newman P E.Can reduced folic acid and vitamin B12 levels cause deficient DNA methylation producing mutations which initiate atherosclerosis?[J].Med Hypotheses, 1999, 53(5):421-424
Yan T T, Li Q, Zhang X H, et al.Homocysteine impaired endothelial function through compromised vascular endothelial growth factorAktendothelial nitric oxide synthase signalling[J].Clin Exp Pharmacol Physiol, 2010, 37(11):1071-1077
Jiang X, Yang F, Tan H, et al.Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation[J].Arterioscler Thromb Vasc Biol, 2005, 25(12):2515-2521
Hodeib A A, Elsharawy T A, Fawzi H A.Assessment of serum homocysteine,endothelin-1,and nitric oxide levels in behcet's disease[J].Indian J Dermatol, 2010, 55(3):215-220
Khor G H, Froemming G R, Zain R B, et al.DNA methylation profiling revealed promoter hypermethylation-induced silencing of p16,DDAH2 and DUSP1 in primary oral squamous cell carcinoma[J].Int J Med Sci, 2013, 10(12):1727-1739
Jia S J, Lai Y Q, Zhao M, et al.Homocysteine-induced hypermethylation of DDAH2 promoter contributes to apoptosis of endothelial cells[J].Pharmazie, 2013, 68(4):282-286
Zeng X, Dai J, Remick D G, et al.Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes[J].Circ Res, 2003, 93(4):311-320
Hiltunen M O, Yl?-Herttuala S.DNA methylation smooth muscle cells and atherogenesis[J].Arterioscler Thromb Vasc Biol, 2003, 23(10):1750-1753
Kim M，LongT I, Arakawa K, et al.DNA methylation as a biomarker for cardiovascular disease risk[J].PLOS One, 2010, 5(3):e9692-9699
Ying A K，Hassanain H H, Roos C M, et al.Methylation of the estrogen receptor alphagenepromoter is selectively increased in proliferating human aortic smooth muscle cell[J].Cardiovasc Res, 2000, 46(2):172-179
Nesset K A, Perri A M, Mueller C R.Frequent promoter hypermethylation and expression reduction of the glucocorticoid receptor gene in breast tumors[J].Epigenetics, 2014, 9(6):E-p
Christensen B C, Smith A A, Zheng S, et al.DNA methylation,isocitrate dehydrogenase mutation,and survival in glioma[J].J Natl Cancer Inst, 2011, 103(2):143-153
Zawadzki C, Chatelain N, Delestre M, et al.Tissue factor pathway inhibitor-2 gene methylationis associated with low expression in carotid atherosclerotic plaques[J].Atherosclerosis, 2009, 204(2):e4-14
Zhang D, Chen Y, Xie X，et al.Homocysteine activates vascular smooth musclecells by DNA demethylation of platelet-derived growth factor in endothelial cells[J].J Mol Cell Cardiol, 2012, 53(4):487-496
Lee R C, Ambros V.An extensive class of small RNAs in Caenorhabditis elegans[J].Science, 2001, 294(5543):862-864
Raisch J, Darfeuille-Michaud A, Nguyen H T.Role of microRNAs in the immune system,inflammation and cancer[J].World J Gastroenterol, 2013, 19(20):2985-2996
Cirera-Salinas D, Pauta M, Allen R M, et al.Mir-33 regulates cell proliferation and cell cycle progression[J].Cell Cycle, 2012, 11(5):922-933
Singh T R, Gupta A.Suravajhala PChallenges in the miRNA research[J].Int J Bioinform Res Appl, 2013, 9(6):576-583
Varela M A, Roberts T C, Wood M J.Epigenetics and ncRNAs in brain function and disease: mechanisms and prospects for therapy[J].Neurotherapeutics, 2013, 10(4):621-631
Ji R, Cheng Y, Yue J, et al.MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascularneointimal lesion formation[J].Circ Res, 2007, 100(11):1579-1588
Hergenreider E, Heydt S, Treguer K, et al.Atheroprotective communication between endothelial cellｓand smooth muscle cells through miRNAs[J].Nat Cell Biol, 2012, 14(3):249-256
Xu P, Vernooy S Y, Guo M, et al.The Drosophila microRNA Mir-14 suppressescell death and is required for normal fat metabolism[J].Curr Biol, 2003, 13(9):790-795
Tserel L，Runnel T，KisandK.MicroRNA expression profiles of human blood monocyte-derived dendritic cells and macrophages reveal miR-511 as putative positivere gulator ofToll-likereceptor4[J].J Biol Chem, 2011, 286(30):26487-26495
Fernandez-Hernando C, Baldan A.MicroRNAs and Cardiovascular Disease[J].Curr Genet Med Rep, 2013, 1(1):30-38
Rykov S V, Khodyrev D S, Pronina I V, et al.Novel miRNA genes methylated in lung tumors[J].Genetika, 2013, 49(7):896-901
Saito Y, Liang G, Egger G, et al.Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells[J].Cancer Cell, 2006, 9(6):435-443
Saito Y, Suzuki H, Tsugawa H, et al.Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells[J].Oncogene, 2009, 28(30):2738-2744
Lujambio A, Ropero S, Ballestar E, et al.Genetic unmasking of an epigenetically silenced microRNA in human cancer cells[J].Cancer Res, 2007, 67(4):1424-1429
He L, He X, Lim L P, et al.A microRNA component of the p53 tumour suppressor network[J].Nature, 2007, 447(7148):1130-1134
Lodygin D, Tarasov V, Epanchintsev A, et al.Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer[J].Cell Cycle, 2008, 7(16):2591-2600
Xing T J, Xu H T, Yu W Q, et al.Methylation regulation of liver-specific microRNA-122 expression and its effects on the proliferation and apoptosis of hepatocellular carcinoma cells[J].Genet Mol Res, 2013, 12(3):3588-3597
Wang L Q, Kwong Y L, Kho C S, et al.Epigenetic inactivation of miR-9 family microRNAs in chronic lymphocytic leukemia--implications on constitutive activation of NF-kB pathway[J].Mol Cancer, 2013, 12(2):173-186
Liu X, Chen X, Yu X, et al.Regulation of microRNAs by epigenetics and their interplay involved in cancer[J].J Exp Clin Cancer Res, 2013, 32(1):86-96
Lehmann U, Hasemeier B, Christgen M, et al.Epigenetic inactivation of microRNA gene hsa-mir- 9-1 in human breast cancer[J].J Pathol, 2008, 214(1):17-24
Saito Y, Saito H, Liang G, et al.Epigenetic Alterations and MicroRNA Misexpression in Cancer and Autoimmune Diseases: a Critical Review[J]. Clin Rev Allergy Immunol, 2013, Epub ahead of print
Fabbri M, Garzon R, Cimmino A, et al.MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B[J].Proc Natl Acad Sci USA, 2007, 104(40):15805-15810
Kikuyama M, Takeshima H, Kinoshita T, et al.Development of a novel approach,the epigenome- based outlier approach,to identify tumor-suppressor genes silenced by aberrant DNA methylation[J].Cancer Lett, 2012, 322(2):204-212
Rakyan V K, Hildmann T, Novik K L, et al.DNA methylation profiling of the human major histocompatibility complex: a pilot study for the human epigenome project[J].PLoS Biol, 2004, 2(12):e405-
Abbott A.Project set to map marks on genome[J].Nature, 2010, 463(7281):596-597
