Abstract：A new cellular senescence inhibited gene (CSIG) was cloned based on a previously obtained fragment with potential of higher expression in young versus senescent 2BS cells by rapid amplification of cDNA ends. The full length of CSIG cDNA is 1961 bp and encodes 490 amino acids. The CSIG mRNA expresses in many important human tissues with different extent. Its protein product located in the specific sites of nuclear might be concentrated in nucleolus.By ectopic expression,it was found that CSIG could delay cellular senescence of 2BS and extend cell lifespan,suggesting that it might participate in ribosomal biosynthesis or act as a transcription co\|factor to regulate cellular senescence.
收稿日期: 2003-10-20
引用本文:
郭淑贞,张宗玉,童坦君. 衰老相关新基因CSIG的cDNA克隆和功能[J]. 中国生物化学与分子生物学报, 2003, 19(05): 612-617.
GUO Shu\|zhen, ZHANG Zong\|yu,TONG Tan\|jun *. cDNA Cloning and Function of a New Cellular Senescence-associated Gene CSIG. Chinese Journal of Biochemistry and Molecular Biol, 2003, 19(05): 612-617.
