PDF(6439 KB)
妇女孕期叶酸增补不足会导致胎儿脑组织中组蛋白去甲基化酶KDM5A表达下降,进一步介导其下游的H3K4me3修饰激活神经发育基因Axin2、Atoh1的表达,导致胎儿神经管畸形的发生
封面图片设计 任佳欣, 李建婷
中国生物化学与分子生物学报 ›› 2024, Vol. 40 ›› Issue (5) : 731.
PDF(6439 KB)
PDF(6439 KB)
妇女孕期叶酸增补不足会导致胎儿脑组织中组蛋白去甲基化酶KDM5A表达下降,进一步介导其下游的H3K4me3修饰激活神经发育基因Axin2、Atoh1的表达,导致胎儿神经管畸形的发生
Insufficient folic acid supplementation during pregnancy can decrease the expression of histone demethylase KDM5A in fetal brain tissue. This in turn further mediates the downstream H3K4me3 modification to activate the expression of neurodevelopmental genes Axin2 and Atoh1, which results in fetal neural tube defects
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