Autophagy is an evolutionaryly conserved mechanism for the degradation of intracellular substances. It is responsible for the recycling of metabolites and the maintenance of intracellular homeostasis. Autophagy may protect tumor cells from undergoing apoptosis when exposed to anticancer agents;it can also be a mechanism of tumor cell death, especially in cells with defective apoptotic machinery. Thus, autophagy functioned like a doubleblade sword in drug resistant cancer cells. In this review, we focus on the discussion about the molecular mechanism of autophagy and its connection in cancer drug resistance.
ZHANG Hai-Liang, TANG Sheng-Song.
Autophagy and Drug Resistance in Cancer[J]. Chinese Journal of Biochemistry and Molecular Biology, 2014, 30(3): 224-232
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