多种功能的poly(C)-结合蛋白

霍丽蓉, 王晓民

中国生物化学与分子生物学报 ›› 2011, Vol. 27 ›› Issue (3) : 205-211.

PDF(390 KB)
PDF(390 KB)
中国生物化学与分子生物学报 ›› 2011, Vol. 27 ›› Issue (3) : 205-211.
综述

多种功能的poly(C)-结合蛋白

  • 霍丽蓉,王晓民
作者信息 +

Multifunctional Poly(C)-binding Proteins

  •  HUO  Li-Rong, WANG  Xiao-Min
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文章历史 +

摘要

细胞内的RNA一般不会单独存在,而是与各种各样的RNA结合蛋白(RBPs)绑定在一起,形成核糖核蛋白复合体(RNP complexes)影响着RNA的加工与转归. Poly(C)结合蛋白是一类重要的RNA结合蛋白,可分为两组:hnRNP K 和PCBP14. 它们以序列特异的方式与核酸嘧啶富含区相结合. 这类蛋白具有共同的结构模体(motif),即hnRNP K 同源(KH)域. KH域是与mRNA结合的结构基础,也是机体内调控系统的组成部分,可使得Poly(C)结合蛋白参与蛋白/核酸、蛋白/蛋白之间的相互作用,范围涉及复制、转录、mRNA稳定和翻译控制过程等. 对Poly(C)结合蛋白功能的深刻认识可使我们洞察多种疾病的病理生理过程.

Abstract

The processing and ultimately turnover of mRNA are complex processes that are highly regulated. Within a cell, RNA is usually not in a naked form. It forms ribonucleoprotein (RNP) complexes with various RNAbinding proteins (RBPs), thereby influencing processing and turnover events. Poly(C)binding proteins (PCBPs), generally known as RBPs, interact in a sequencespecific fashion with singlestranded poly(C). They can be divided into two groups: hnRNP K and PCBP14. PCBPs and hnRNP K share a common structural motif, the hnRNP K homology (KH) domain, which provides a structural basis for mRNA binding. The KHdomains are components of a modular system, which enables the proteins to be engaged in both protein/nucleic acid and protein/protein interactions. The latter interactions are involved in cell signaling events. As components of different mRNAprotein complexes, PCBPs and hnRNP K have been identified as factors involved in regulating duplication, transcription, mRNA stability and translation. They have also been found related to some pathological processes, such as HutchinsonGilford Progeria syndrome, virus infections and malignancy.

关键词

核不均一核糖核蛋白 / hnRNP K 同源(KH) 域 / RNA结合蛋白 / 转录后调控

Key words

hnRNPs / hnRNP K homology (KH) domain / RNA binding proteins / post-transcriptional regulation

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导出引用
霍丽蓉, 王晓民. 多种功能的poly(C)-结合蛋白[J]. 中国生物化学与分子生物学报, 2011, 27(3): 205-211
HUO Li-Rong, WANG Xiao-Min. Multifunctional Poly(C)-binding Proteins[J]. Chinese Journal of Biochemistry and Molecular Biology, 2011, 27(3): 205-211
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