Abstract：Ligustrazine is an alkaloid extracted from the root of Ligustium wallichii Frachet which has long been known to be effective in"improving the circulation of blood and relieving clot formation"(HUOXUE HUAYU) in Chihese traditional medicine. The chemical structure of Ligustrazine has been determined and synthetic product has been put on the market.The clinical trials revealed that Ligustrazine was effective in the treatment of patients with angina pectoris in coronary heart diseases and acute occlusive cerebro-vascular diseases as well.our in vitro study proved that Ligustrazine could strongly inhibit platelet aggregation induced by ADP, collagen, thrombin, and reduce the production of MDA from platelets; but showed no inhibitory effect on the exogeneous arachidonic acid-induced platelet aggregation. However, while injected intravenously into rabbits prior to the administration of large doses of sodium arachidonate, which would invariably lead to sudden death, Ligustvazine could potentiate the inhibitory action on arachidonic acid-induced platelet aggregation similar to that of the solution of incubated rabbit arterial rings and protected the rabbits from death.
秦为熹,齐治家. 川芎嗪对血小板聚集功能的影响及其作用机制的探讨[J]. 中国生物化学与分子生物学报, 1985, 1(03): 59-64.
Qin,Wei Xi Qi, ZhiJiaBeijing College of Trfaditional Chinese Medicins. STUDIES ON THE EFFECT OF LIGUSTRAZINE ON PIATEIETS AGGREGATION AND ITS MECHANISMS. Chinese Journal of Biochemistry and Molecular Biol, 1985, 1(03): 59-64.
