2015年《中国生物化学与分子生物学报》稿源稳定增加，载文质量明显提高。成绩的背后包含着我刊审稿专家的辛勤劳动，感谢各位审稿专家在百忙之中为我刊审阅稿件、把关质量。《中国生物化学与分子生物学报》编辑部值此新春之际特向2015年度本刊审稿专家致以新年的祝福和诚挚的感谢！2015年度共有217位专家为我刊审稿，其中审稿3篇及以上的被评为优秀审稿专家。

The expression regulation of interspersed repeats and imprinting genes is mainly controlled by DNA methylation in mammalian germ line cells. It is important for the gametogenesis and embryonic development. During the mammalian trans-generational cycle of germ line cells, the genome global DNA methylation is erased in primordial germ cells and reestablished during the gametogenesis. After the fertilization, DNA is demethylated (except for imprinted genomic regions) in cleavage stage of embryos, while remethylated in blastomere differentiation. During the sophisticated biological process, the DNA methylation erasure and reestablishment of interspersed repeats and imprinted genes are not only controlled by endogenous factors but also affected by diseases or environmental stresses. DNA methylation mutations in parents’ germ line cells even can be inherited by offsprings. Up to date, it is still not clear about detailed mechanisms which control the DNA methylation of interspersed repeats and imprinted genes. In this review, we introduce interspersed repeats and imprinted genes, focus on the molecular mechanism of DNA methylation erasure and reestablishment, and summarize new findings about the regulation of DNA methylation of interspersed repeats and imprinted genes in mammalian germ line cells.