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�й����ﻯѧ���������ѧ�� 1993, Vol. 9 Issue (04 ):460-460     DOI:
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Regulation of the Antibody Expression in �� Chain Transgenic Mouse by Cytokines
Han, Hua Wang, Cheng-ji Akira Shimizu~* Tasuku Honjo~* (Department of Biochemistry, The Forth Millitary Medical University, Xi-an 710032) (* Department of Medical Chemistry, Kyuto University, Faculty of Medicine, Kyoto, Japan 606)

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Abstract�� Transgenie mouse bearing rearranged immunoglobulin �� chain gene can express chimeric antibody composed of transgenic variable and endogenous constant regions. The work presented here shows that the isotype of the chimeric-antibody is regulated by various factors: LPS induces ��2b, LPS+IL4 induces ��1, and LPS+TGF-�� induces �� type chimeric antibodies. The stractures of mRNA of each isotype were determined, prior to the expression of chimeric antibody mRNA, the germline transcripts of corresponding constant region genes were induced. These results suggest that trans-splicing may participate in antibody gene expression.
Keywords�� Antibody   Gene expression   Transgenic mouse   Chimeric antibody   Transsplicing      
Received 1990-05-27;
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����.ϸ�����Ӷ��˦���ת����С������ĵ��� [J]  �й����ﻯѧ���������ѧ��, 1993,V9(04 ): 460-460
.Regulation of the Antibody Expression in �� Chain Transgenic Mouse by Cytokines [J]  Chinese Journal of Biochemistry and Molecular Biol, 1993,V9(04 ): 460-460
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http://cjbmb.bjmu.edu.cn/CN/     ��     http://cjbmb.bjmu.edu.cn/CN/Y1993/V9/I04 /460