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Simulation on Botanic Rubisco Active Center
XIONG Xiao ran, CHEN Wei mei *, FENG Sheng yan, GUO Ming xiong, AI Jian yu, WU Bin (School of Life Sciences, Wuhan University, Wuhan 430072, China)
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Supporting Info
ժҪ ͨ����벻ͬ����ϵ�ֲ��Rubisco������ṹ���ص��ȽϷ��� ,����Rubisco�Ļ��Բ�����������һ��Loop6����������ɵ� ;����������������ĵĽ�ϻ���ɻ������ľ�Ĺ���仯 .��һ����SwissPDBViewer���ģ�ⲻͬ����ֲ��Rubisco�����������Loop������������ .������ ,�� 3��Lys�л�Lys2 0 1��Lys334��Lys175��Rubisco�Ƿ��ڻ���״̬������� ,��Щ�л�Ľṹ�仯�Է�����ƿ�������Ҫ�IJο���ֵ
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Abstract ��
Through superposition of Rubisco combined with different ligands, it was found that loop6 in the C domain led to a difference between activated Rubisco and non activated one and that the metal ion binding induced a large structural change in active center. The positional relation and hydrogen bond interaction between the residues in active site and this loop region of Rubisco combined with different ligands were simulated through SwissPDBViewer. The results showed that three Lys residues����Lys201, Lys334 and Lys175, were related to the activity of Rubisco. The structural changes in these residues will give instruction to molecular design.
Keywords ��
Rubisco
active center
simulation
Received 2002-09-24;
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